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Lipoic acid and arginine for the liver

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Liver problems can be caused by many diseases. Some of them are dangerous for a person’s state of health and life, because this organ not only produces bile, which is necessary for digesting food, but also is a natural filter of our body that cleanses the blood of harmful compounds using the biochemical substances produced in it, which are involved in metabolism.

So far, medicine cannot offer the patient such medicines and procedures that would make it possible to live without this vital organ. Even liver transplantation or its partial removal always brings a lot of suffering, limitations and the need to undergo complex treatment courses to the patient's life.

In this article, we will introduce you to the main signs of problems with the liver and a drug such as lipoic (or thioctic) acid. It can have a beneficial effect on the functioning of this vital organ in diseases such as hepatitis and hepatoses.

What signs indicate liver problems?

Pathology of the liver can manifest itself with various symptoms. Most often these are:

  • tongue coating
  • dark circles under the eyes,
  • brown pigmentation on the body in the form of spots,
  • bad skin odor
  • rosacea
  • bad breath
  • pain or heaviness in the right hypochondrium.

How does lipoic acid affect the liver?

Lipoic acid was first isolated from yeast and liver in 1948. Its synthesis was carried out in 1952, and after that studies began on the effect of this substance on blood sugar in diabetes. As a result, in 1977, scientists found that lipoic acid is able to have a positive effect not only on the pancreas, but also on the liver.

In chronic liver diseases, people constantly suffer from the toxic effects of free radicals on their body. To neutralize them, antioxidants are needed, which must be introduced into the body additionally. One of these substances is lipoic acid - a coenzyme of certain enzymes that regulate fat and carbohydrate metabolism.

Providing a lipotropic effect, this antioxidant prevents the excessive accumulation of fats in the liver cells and their fatty degeneration. This effect is achieved due to the fact that lipoic acid can reduce the consumption of such an intrahepatic antioxidant as glutathione.

How does lipoic acid enter our body?

The human body itself produces lipoic acid in small quantities. Basically, she enters it with food.

Lipoic acid is found in the following foods:

  • fresh milk - 500-1300 mcg,
  • rice groats - 220 mcg,
  • beef liver - 3-7 thousand micrograms,
  • offal - 1 thousand mcg,
  • spinach greens - 100 mcg,
  • beef - 725 mcg,
  • white cabbage - 150 mcg.

In smaller amounts, this antioxidant is also present in other foods:

Normally, the daily dose of this antioxidant for healthy people is 10-50 mg. With liver pathology, it should be at least 75 mg, and with diabetes - 200-600 mg. With an insufficient amount of this vitamin-like substance, the liver suffers from an excess of fats, and such a state of it can lead to the development or worsening of diseases. You can replenish the reserves of this antioxidant by observing the rules of good nutrition or by taking medications containing lipoic acid.

Indications for use

  • Chronic hepatitis
  • chronic alcoholic pancreatitis,
  • chronic cholecystopancreatitis,
  • alcoholic cirrhosis of the liver,
  • chronic heart failure
  • moderate viral hepatitis, proceeding without jaundice or its intensive growth,
  • intoxication accompanied by liver damage caused by poisoning with fungi, sleeping pills, carbon, heavy metal salts or carbon tetrachloride,
  • diabetic polyneuropathy.

Dosage for children and adults

  • Children over 6 years old - 12-24 mg 2-3 times a day,
  • adults - 50 mg 3-4 times a day.

The drug should be taken after meals. The course of admission is 20-30 days. If necessary, the doctor may recommend repeating it after a month. Patients with diabetes while taking the drug are advised to regularly monitor their sugar levels.

Side effects and signs of overdose

In some cases, taking Lipoic acid leads to the appearance of such undesirable effects:

  • lowering blood sugar
  • digestive disorders (diarrhea, abdominal pain, heartburn),
  • allergic reactions (possible anaphylactic shock or systemic reactions).

With an overdose of Lipoic acid, symptoms of irritation of the mucous membranes of the organs of the gastrointestinal tract, which are expressed in diarrhea and vomiting, may appear. They can be eliminated by temporary discontinuation of the drug and strict adherence to the dose indicated by the doctor with continued administration.

Possible interactions with other drugs

  • potentiates the action of insulin or hypoglycemic drugs for oral administration,
  • loses its effect when combined with ethanol,
  • weakens the action of cisplatin,
  • it can interfere with the normal absorption of iron, magnesium and calcium contained in the preparations (with the joint use of such drugs, the interval between doses of drugs should be at least 2 hours).

Release form

The drug Lipoic acid can be found in pharmacies in the following types:

  • tablets with a shell of 12 or 25 mg (10, 50 or 100 pieces per pack),
  • 2% solution in ampoules of 10 pieces per pack.

Lipoic acid analogues are such drugs:

  • Tiogamma
  • Berlition 300,
  • Ticket
  • Protogen
  • Tiolepta
  • Thioctacid BV

Which doctor to contact

To find out if the patient needs additional intake of lipoic acid, you should consult a physician. if the diagnosis is already known, an examination by a gastroenterologist or hepatologist will be required. People with diabetes need to find out about this drug from an endocrinologist. Consulting a neurologist will also be useful, because lipoic acid has a beneficial effect on the nervous system.

What is it like?

Alpha lipoic acid (thioctic, vitamin N) has the same biological value as vitamins and minerals, is a good antioxidant, and is involved in the metabolism of fats and carbohydrates. It can be used as a prophylactic against viruses and treatment of tumors. Under the influence of a fatty acid, glucose is converted into energy. Vitamin N normalizes cholesterol levels in the blood, removes toxins and toxins, has a beneficial effect on the nervous system. As a medicine, it is produced in the form of a yellow crystalline powder.

Where is?

Lipoic acid is produced in the body independently. Additionally, it can be taken as a medicine or in preparations containing thioctic acid (“Berlition”, “Thioctacid”). Partially, it can be obtained from food products: legumes (peas, beans, lentils), bananas, spinach, cabbage, rice. The highest content of substances in such products of animal origin:

  • heart, kidneys, liver,
  • beef,
  • milk products.

Alpha-lipolic acid should be administered under medical supervision. An incorrect dosage of vitamin N can be harmful.

What is useful?

Lipoic acid has the following beneficial properties:

    The drug will add energy and help in the fight against diseases.

restores and nourishes nerve cells,

  • Helps the liver store glycogen
  • normalizes blood glucose
  • provides metabolism (fats and carbohydrates),
  • helps generate energy in the cells,
  • relieves intoxication after poisoning with alcohol or heavy metals,
  • boosts immunity
  • normalizes intestinal microflora.
  • Back to the table of contents

    Liver benefits

    Vitamin N deficiency in the body is manifested by liver pathologies. Harmful radicals destroy the gland, and lipoic acid is a powerful weapon against them. It restores hepatocytes and has a protective effect. Due to its participation in lipid metabolism, thioctic acid removes excess fat from the body and does not allow fatty degeneration of liver tissue. Used for hepatitis, cirrhosis, fatty hepatosis.

    Application

    In addition to liver pathologies, thioctic acid treats such diseases:

    • joint diseases - arthrosis, arthritis,
    • asthma,
    • glaucoma,
    • cystic fibrosis.

    As preventive measures, take 12-25 mg per day. Therapy for the liver is prescribed in this way:

    • With fatty hepatosis, 50 mg 3-4 times a day 30 minutes before meals or after meals.
    • For other diseases of the gland, the daily dosage is 200-600 mg.
    • Swallow vitamin N without chewing, drinking water or juice.
    • For a quick effect, you can inject the drug - 1-4 ml of the solution is administered intramuscularly.
    Back to the table of contents

    How to determine the deficit?

    Due to the fact that fat-soluble acid is produced by the body, its absence is impossible. Therefore, acute signs of its lack are not observed. If vitamin N is insufficient due to an unbalanced diet, you may experience the following symptoms:

    • fast fatiguability,
    • weakness,
    • swelling
    • disorders of the nervous system.
    Back to the table of contents

    What is arginine?

    It is an amino acid that is produced from other acids in the adult body. The lack of substance is compensated by preparations with its content. Contained in such products:

    After entering the liver, arginine breaks down into ornithine and nitric oxide. The second substance is important for cells and tissues, as it carries oxygen and iron to them. Amino acid performs the following functions:

    • nourishes muscle tissue
    • promotes the transport of nutrients to cells,
    • saturates cells with oxygen and hormones,
    • participates in the formation of protein,
    • stimulates nerve fiber impulses,
    • forms muscles.

    Nitric oxide is a vital substance. It is produced in the body only with the help of arginine.

    How to recognize liver problems

    Various symptoms may suggest that something is wrong with the liver. In most cases, such signs can be tracked by the appearance of a person. It can be: - dark pigment spots on the skin, - green patches on the tongue, - red whites of the eyes, - swelling of the eyelids, - unpleasant smell of breathing and body, - unexplained skin itching, - an abundance of small pink eels, - dark circles around eye. Most of these signs are confirmation of chronic intoxication of the body, as a result of various liver diseases.

    Action of lipoic acid

    Liver cells cannot perform their function in the previous mode due to metabolic disorders, the intake of a large amount of toxins (including alcohol), an excess of medications taken and much more. When the liver cell cannot completely remove the excess of fat received from food, it is oversaturated with it and gradually the patient develops fatty liver hepatosis. With hepatosis, cells do not perform their functions, if proper treatment is not received, they degenerate into connective tissue cells. This phenomenon is known as cirrhosis. In chronic liver diseases, an important point is to facilitate its work on detoxification and lipid metabolism of the human body. Lipoic acid regulates the fat (lipid) metabolism in the body and removes excess fat and toxins.

    To prevent chronic liver diseases, it is recommended to carry out ultrasound at least 1 time per year.

    In 2005, Russian doctors of the National Medical and Surgical Center of the Ministry of Health of the Russian Federation conducted a scientific study whose purpose was to study the effectiveness of the use of lipoic acid in the treatment of liver diseases. For a month, patients with non-alcoholic hepatosis took the drug 3 times a day.

    To eliminate side effects and not harm your body, take medications only after consulting a specialist.

    At the end of the treatment period, a series of tests were performed that confirmed a significant improvement in the condition of patients, a decrease in the size of the liver and an increase in its echogenicity during ultrasound examination.

    Lipoic acid, its effect on the liver

    Unfortunately, sometimes the liver fails. You can recognize this by the following simple symptoms:

    swelling of the eyelids and redness of the whites of the eyes,

    - dark circles around the eyes (appear from stress, lack of sleep, kidney and liver diseases),

    - rosacea (they are also called vulgar),

    - plaque in the tongue (usually green),

    - dark spots on the skin (this is not always a cosmetic defect, but often a symptom of illness),

    - itching of the skin for no obvious reason (the first signal that the body is uncomfortable for some reason!),

    bad breath

    - unpleasant body odor.

    With problems in work, the liver becomes powerless against free radicals that destroy organ cells. Alpha lipoic acid helps restore liver cells, protect the main gland of our body. Responsible for fat and carbohydrate metabolism, lipoic acid cleanses the liver from accumulations of harmful radicals in case of disruption of the latter. Thioctocide is also used to treat hepatic fatty liver disease - it occurs when it is impossible to remove excess fat and overload the liver cells with them.

    Among the causes of fatty liver hepatosis are alcoholism, excess weight, and some chronic diseases. Diabetes mellitus, gastrointestinal diseases, atherosclerosis, hypertension, malnutrition can also become triggers for the disease.

    - impaired coordination of movements,

    - discomfort in the right hypochondrium.

    With the progression of fatty hepatosis, nausea is constant, swelling appears, vision decreases, digestion problems occur, a rash or allergy may appear on the skin. If untreated, liver failure occurs - jaundice, weakness, impaired coordination, aversion to food.

    Alpha lipoic acid is used to treat the liver from fatty degeneration, cirrhosis, hepatitis, poisoning. Thioctacid removes excess fat from the tissues of the main gland, which the organ itself cannot cope with.

    Lipoic acid for the liver - use, dosage

    Alpha lipoic acid for the treatment of liver diseases is prescribed by a doctor. Only he determines the dose and dosage regimen. It is not recommended to prescribe drugs for oneself independently. This can lead to allergies or other side effects.

    Lipoic acid is prescribed after meals or half an hour before meals, three to four times a day, fifty milligrams for hepatic fatty liver. 200-600 mg of thioctacide are taken for other liver diseases. The duration of treatment is determined by taking tests on a regular basis - triglycerides, bilirubin, cholesterol, lipoproteins of different densities.

    Lipoic acid for the treatment of liver and other diseases is available in several dosage forms - powder at 0.025 g, a solution of 0.5% for injection, tablets at 0.012 and 0.025 g. It is recommended to swallow thioctacid without chewing, drink a couple of sips of water. Water can be replaced with mineral water, vitamin N can be washed down with compote or juice. You can not drink milk.

    If injections of lipoic acid are made, then 1-4 ml of solution is put inside the muscle, usually they go from taking injections to taking tablets. Alpha lipoic acid quickly enters the bloodstream through injection, so they begin treatment with them. A full course of treatment on average takes 20-30 days, is interrupted for a month and starts again.

    Lipoic acid is freely absorbed through the intestines. The concentration in the blood reaches 5 mcg, excreted in the urine from the body. You can not combine taking thioctacid and sugars - glucose, fructose. With sugars, vitamin N starts a chemical reaction, forms compounds that are difficult to dissolve.

    When treating the liver with lipoic acid, one should remember about the possibility of an overdose. Its symptoms are itchy skin, allergic rashes, diarrhea, nausea and vomiting, pain in the head, abdomen, and in some cases anaphylactic shock. If these signs appear, consult a doctor immediately, stopping the allergen.

    Lipoic acid treats the liver, but can aggravate other diseases. If you have gastritis with an increase in acidity, peptic ulcer, duodenal ulcer - take thioctacid carefully. With diabetes and allergies, the measure in the treatment of alpha lipoic acid should also be observed.

    Lipoic acid is also used to prevent diseases of the liver, pancreas, other organs, and weight loss. For these purposes, buy supplements with 12-25 mg of vitamin N, drink two to three times a day. The prophylactic dosage can be increased to 100 mg, the course in such cases is 20-30 days. Then a break is made for a month, and the course is repeated.

    Composition and mechanism of action

    Lipoic acid is a biologically active substance. This compound is also called thioctic acid, alpha lipoic acid and vitamin N. In the pharmaceutical industry, a salt of thioctic acid is used.

    The tablets contain 25 or 50 mg of lipoic acid and auxiliary components. The active component has anti-inflammatory, immunomodulating, antioxidant, regenerating, hepatoprotective, hypolipidemic, hypoglycemic and choleretic effects.

    • Relieves local inflammatory processes. In view of this, vitamin N-based drugs can be used in the treatment of chronic hepatitis (drug, alcohol, viral).
    • Accelerates local regenerative processes.
    • Normalizes the blood circulation process.
    • It prevents the development of fibrosis - the transformation of healthy liver cells into connective tissue. Fibrosis is characteristic of cirrhosis and oncological pathologies.
    • It has an insulin-like effect. Vitamin N replaces insulin if it is deficient. Lipoic acid also improves glucose utilization. In view of this, the medicine is often used as part of the complex treatment of diabetes.
    • It has a hepatoprotective effect. Alpha lipoic acid protects hepatocytes from destruction, provides a membrane-stabilizing effect.
    • Eliminates stagnation of bile and stabilizes the work of the gallbladder as a whole. There is evidence that thioctic acid normalizes the synthesis and passage of bile, and also reduces the lithogenicity of bile, that is, prevents the formation of cholesterol stones in the body.
    • Increases the body's resistance to infectious agents and viruses.
    • Normalizes fat metabolism. When using tablets, the level of bad cholesterol in the blood decreases. Also, drugs based on thioctic acid help “dissolve” cholesterol plaques.
    • Prevents the development of fatty hepatosis.
    • It has an antioxidant effect, neutralizes free radicals.

    Thioctic acid also has a detoxifying effect. The component accelerates the elimination of toxins and toxins from the body, thereby normalizing the "filtration" function of the liver.

    Instructions for use of the drug

    Lipoic acid for the liver is very useful, as it has a hepatoprotective and choleretic effect. The main indications for the use of the drug are cirrhosis, fatty liver hepatosis, alcoholic hepatitis, acute liver failure, drug hepatitis, viral hepatitis with increasing jaundice.

    The list of indications also includes chronic pancreatitis, non-calculous cholecystitis, a chronic form of cholecystopancreatitis, intoxication (salts of heavy metals, alcohol, drugs, mushrooms, carbon), type 2 diabetes mellitus, diabetic polyneuritis, alcoholic polyneuropathy, diabetic polyneuropathy, atherosclerosis, and atherosclerosis, psoriasis.

    Thioctic acid-based medicines can be used after a course of treatment with prednisolone. Vitamin N prevents the development of withdrawal syndrome. Thioctic acid is also used in the treatment of obesity. It is allowed to take tablets purely for preventive purposes.

    Consider the dosage and rules of administration. The instructions for use say that you need to drink tablets 30 minutes before eating. In acute disorders of the liver, gall bladder, pancreas, it is better to drink 50 mg 3-4 times a day. For intoxication, diabetes, psoriasis, atherosclerosis, alcoholic and diabetic polyneuropathy, 300-600 mg per day should be taken. If the medicine is used for preventive purposes, then it is enough to use 150-200 mg per day.

    The duration of the treatment course is set individually. On average, therapy lasts 3-5 weeks. The course can be repeated after 1-2 months.

    Contraindications and side effects

    It is strictly forbidden to take thioctic acid for men and women suffering from hypersensitivity to the active or auxiliary components of the tablets. No medication is prescribed for children under the age of 18 years.

    The list of relative contraindications includes the period of breastfeeding, pregnancy, gastritis with increased acidity of gastric juice, gastric ulcer and 12 duodenal ulcer in the acute stage.

    1. Allergic reactions. Itching, burning, urticaria, swelling, hyperemia, Quincke's edema are possible. In rare cases, anaphylactic reactions have been observed.
    2. Digestive upsets. Long-term use of Lipoic acid is fraught with the appearance of a metallic taste in the mouth, diarrhea, nausea, epigastric pain, and colic in the right hypochondrium.
    3. Short-term increase in intracranial pressure.
    4. Muscle cramps.
    5. Migraine, dizziness.
    6. Propensity to bleeding, pinpoint hemorrhages.
    7. Diplopia.
    8. Disorders in the work of the respiratory system.

    An overdose is fraught with hypoglycemia, anaphylactic shock, and vomiting. In case of an overdose, symptomatic treatment is performed.

    Reviews of Lipoic Acid

    Real reviews of Lipoic acid are mostly positive. According to patients, the drug helps to quickly transfer a chronic disease to the stage of persistent remission. Side effects, according to patients, do not appear.

    Negative comments are extremely rare. As a rule, people who do not follow the instructions for use speak badly about the tablets, as a result of which they did not feel the therapeutic effect.

    Reviews of doctors about Lipoic acid are positive. According to doctors, the drug perfectly helps to achieve remission of diseases of the hepatobiliary system. Doctors also recommend using this drug to cleanse the liver after intoxication or prolonged use of corticosteroids / antibiotics / cytostatics.

    Based on the foregoing, we highlight the pros and cons of the drug. The advantages are:

    • Relatively low cost.
    • Good compatibility with other hepatoprotectors.
    • The presence of choleretic and hypoglycemic action.
    • The possibility of use in pathologies of the pancreas.
    • High performance.

    The disadvantage of the drug is the inability to use it during pregnancy, lactation and the treatment of liver diseases in children.

    Tiolepta

    Tiolepta is a medicine based on thioctic acid. The drug is produced in Russia by the pharmaceutical company Canonpharm Production. The drug is produced in the form of tablets and solution. The price of tablets (60 pieces of 600 mg) is about 1200 rubles, and the solution of the same name (50 ml of 10 ampoules) costs about 1,500 rubles.

    The active ingredient is lipoic acid. As already noted above, this compound has an antioxidant, choleretic, hepatoprotective, hypoglycemic effect.

    Thioctic acid has the ability to bind free radicals and improve trophic processes. The active component takes part in the normalization of carbohydrate and fat metabolism, lowers the level of harmful cholesterol in the blood and prevents the development of fatty liver hepatosis.

    Tyolepta is used in the treatment of many diseases. The main indications for use are:

    1. Cirrhosis.
    2. Chronic hepatitis An effective medication for viral, acute, chronic, infectious, medicinal and alcoholic hepatitis.
    3. Alcohol intoxication, "alcoholic liver disease."
    4. Psoriasis.
    5. Atherosclerosis, lipid metabolism disorders.
    6. Polyneuropathy (alcoholic or diabetic).
    7. Type 2 diabetes.
    8. Chronic infectious pathologies, including HIV.
    9. Fatty degeneration of the liver.
    10. Liver failure.

    Take the tablets inside before meals. The optimal daily dose is 300-600 mg, if necessary, the dose can be increased. It is recommended to use the medicine for 3-5 weeks, after which you can take a break and repeat the course.

    As for the solution, it is administered intravenously. 50 ml of solution is administered per day. It is recommended to use the medication for 2-4 weeks. If necessary, you can combine the solution with tablets.

    Tielept is contraindicated in case of hypersensitivity to the components of the drug, pregnant and lactating women, children under the age of 18, lactose intolerance, lactase deficiency, glucose-galactose malabsorption, gastritis with increased acidity, gastric ulcer and 12 duodenal ulcer in the acute stage.

    • Tablets. They can provoke heartburn, flatulence, diarrhea, abdominal pain, allergic and anaphylactic reactions. When using high doses, dizziness, increased sweating, hypoglycemia, and migraine are possible.
    • Solution. After its introduction, allergic reactions, muscle cramps, bifurcation of vision, thrombocytopenia, thrombophlebitis, minor hemorrhages, short-term increase in intracranial pressure, shortness of breath, hypoglycemia may appear.

    Caution should be used in patients with Tieolept for diabetics who take hypoglycemic drugs or undergo insulin therapy.

    Spirulina

    Spirulina is a good substitute for Lipoic Acid. This medication is produced by the companies Biosolar, Prombiotechnika, Solgar. Available in tablet form. The average cost of one package (120 tablets) is 400 rubles.

    The active substance is a medicinal raw material, which is obtained from the blue-green microalgae of spirulina. The extract contains lipoic acid, amino acids, fatty acids, pigments, vitamins, minerals (calcium, phosphorus, sodium, iron, magnesium, zinc, potassium, selenium, iodine).

    Spirulina has a radioprotective, hepatoprotective, antioxidant, anti-inflammatory and choleretic effect. Also, the drug has a hypoglycemic effect.

    Indications for use:

    1. Liver pathologies - cirrhosis, fatty degeneration of the liver, hepatitis, alcoholic liver disease, liver failure.
    2. Gynecological diseases.
    3. Diabetes.
    4. Anemia.
    5. Oncological pathologies.
    6. Obesity.
    7. Age-related hyperkeratosis.
    8. Pathology of the cardiovascular system.
    9. Atherosclerosis.
    10. Psoriasis.
    11. Chronic infectious diseases.

    It is recommended to take 1-2 tablets 3 times a day. The duration of treatment is 2-3 weeks. Spirulina is contraindicated in case of hypersensitivity to the active component, gallstone disease, calculous cholecystitis, nephrolithiasis. Pills are not prescribed for pregnant and lactating women, as well as children under the age of 18 years.

    When using tablets, no side effects appear. Allergic reactions have been noted only occasionally.

    Lipoic acid and arginine for the liver

    A sufficient amount of arginine and lipolic acid in the body is necessary for the liver. Substances are synthesized by the body, but must be additionally absorbed from food. A deficiency of amino acids and vitamin N can lead to metabolic disorders and stop the regeneration of liver cells. The pathology of the body is treated with arginine or thioctocide as drugs.

    Lipoic acid: instructions for use, price, reviews, analogues of the drug for the liver

    Normalize the functionality of the liver and gall bladder through the use of hepatoprotectors. Essential phospholipids, bile acids, amino acids are most often used.

    But many patients prefer drugs based on lipoic acid. Such medicines have anti-inflammatory, immunomodulatory, hepatoprotective and choleretic effects.

    Lipoic acid is available in tablet form. They produce medicine URALBIOFARM and MARBIOFARM. Domestic medicine has a relatively low cost - tablets cost about 80-100 rubles (50 tablets of 25 mg).

    Liver disease

    Liver disease is a term that describes a wide range of liver problems. Often, liver diseases are very dangerous and fatal, because the liver is a filter of our body. You can help the liver cleanse with alpha lipoic acid.

    The liver is a very important vital organ; today there is no medical procedure that would allow a person to live without a liver. The liver may be partially removed or transplanted, but with complications and complex medical treatment. The main function of the liver is detoxification of the body from toxins and toxins entering our body through food, alcohol, and respiratory organs.

    The liver also synthesizes proteins and produces biochemical substances involved in the process of digestion and metabolism. Liver diseases are accompanied by yellowing of the skin, which is caused by an increase in the level of bilirubin (bile pigment) in the human body.

    Typically, the body breaks down the hemoglobin of dead blood cells, which increases the level of bilirubin, which the liver detoxifies and removes from the body. With liver diseases, the detoxification process is suspended, and all negative substances enter the body.

    Major liver diseases: cirrhosis, liver fibrosis, liver abscess, hepatosis, hepatitis.

    How does the liver work?

    Symptoms of Liver Problems

    There are many symptoms that indicate liver problems. But basically the symptoms are expressed by the appearance of the patient:

    • bad breath
    • body odor
    • tongue coating
    • itchy skin
    • red, swollen eyes
    • dark circles under the eyes,
    • rosacea
    • brown spots on the body.

    A little history of lipoic acid

    Alpha-lipoic acid was first discovered in 1948 (it was isolated from yeast and liver), and it began to be synthesized in 1952.

    Later, studies began, and it turned out that lipoic acid lowers blood sugar, so it can be used for diabetes.

    Studies studying the effect of lipoic acid on the liver began in 1977, it turned out that lipoic acid has a positive effect in liver diseases, including chronic ones.

    Where is lipoic acid found?

    Lipoic acid is found in many foods such as (mcg per 1 kg):

    • offal - 1000 mcg
    • beef - 725 mcg
    • beef liver - 3000 - 7000 mcg
    • milk - 500 - 1300 mcg
    • rice - 220 mcg
    • spinach - 100 mcg
    • white cabbage - 150 mcg

    Also, lipoic acid is found in such products:

    Lipoic acid is produced by the human body in small quantities. Deficiency of lipoic acid in the human body can occur with cirrhosis of the liver and other liver diseases.

    Lipoic acid can be replenished with tablets or capsules that are sold at the pharmacy.

    Daily dose of lipoic acid

    Most studies show that the daily rate lipoic acid for a healthy person 10-50 mg, for people who have liver problems 75 mg, but for diabetics 200-600 mg.

    Readers Questions

    Hello! I am 30 years old October 18, 2013 Hello! I am 30 years old. I have a lot of red dots on my body in the form of moles. I have had three dots since childhood.

    Three years ago, when I was pregnant, their number began to appear more, and by this time more and more appeared. The dermatologist said that it was from the liver. The gastroenterologist does not know what it is.

    What can it be and which doctor can I contact? Can I pass some tests?

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    Lipoic Acid Overdose

    High doses of lipoic acid, like any antioxidant, can cause damage to cells in the human body. In case of an overdose, symptoms such as:

    • heartburn,
    • pain in the stomach
    • digestive upset
    • rash similar to urticaria.

    Hepatoprotective properties of alpha lipoic acid

    The liver is the largest gland of the body, which neutralizes toxic substances, produces enzymes and is involved in the digestion process.

    Violation of her work leads to a deterioration in immunity and serious diseases.

    Numerous medical studies have shown that taking lipoic acid protects the liver from inflammation, promotes cell regeneration and has other healing effects on this organ.

    Lipoic acid in xenobiotic poisoning

    • Heavy metal salts (cadmium, mercury, lead, etc.),
    • Industrial refrigerants,
    • Oil refining products,
    • Pesticides and fertilizers
    • Artificial surfactants, etc.

    The liver neutralizes xenobiotics, but is itself exposed to them, as a result of which an inflammatory lesion develops. The regular use of lipoic acid will prevent this process. Research by Dr. Khalaf in 2016 examined its effectiveness to restore liver cells and strengthen immunity.

    “In experiments on rats, lipoic acid reduced toxic liver damage by 20%”

    Forty laboratory rats with symptoms of copper sulfate poisoning received lipoic acid with food for 2 months.

    After the experiment, animal tissue samples were compared with a control group for microtrauma, toxins, and pathological DNA changes.

    It turned out that in rodents that consumed alpha lipoic acid, liver damage rates were lower by an average of 20%.

    It was concluded that lipoate protects organs from oxidative damagecaused by xenobiotic poisoning, promotes tissue regeneration and accelerates the process of neutralization of toxic substances.

    Hepatitis C Prevention

    Hepatitis C is a viral disease that affects the liver and is one of the most common types of hepatitis.

    Without proper therapeutic intervention, it can develop to an acute form or cause cirrhosis of the liver.

    An effective method of counteracting this disease is the use of antioxidants, including lipoic acid. Its effect on the body was described in 1999 by Dr. Barton Burkson.

    Three patients with symptoms of progressive hepatitis C for 7 months took 600 mg of lipoic acid in combination with silymarin and selenmethionine (drugs that accelerate the neutralization of free radicals). The medical examination, which they underwent after the completion of the experiment, revealed the following positive changes in the body:

    • Reducing the concentration of oxidizing agents and viral bodies in the blood,
    • Normalization of platelet count, which reduced the risk of reinfection.

    It turned out that the use of lipoic acid improves the condition of hepatitis patients, increases natural antioxidant defense and inhibits virus replicationcausing infection. Timely strengthening of the body in the early stages of the development of the disease completely eliminates the need for surgical intervention.

    Effect on gallstone disease

    To prevent this disorder, lipoic acid is often used - a powerful antioxidant that eliminates the cause of the disease and has a pronounced symptomatic effect. Scientifically proven that the use of this tool improves the composition of bile and contributes to its renewal. Use in the early stages of the disease prevent stone formation and make the body more resistant to metabolic changes.

    Hepatosis Prevention

    Steatosis or fatty hepatosis is the degeneration of the liver into adipose tissue, which is observed in mild form in about 30% of the Russian population.

    It is known that an excess of lipids (fats) impedes the functioning of organs, increases susceptibility to inflammation, and increases the risk of developing cirrhosis and malignant tumors.

    To counter this disease, it is necessary to eliminate or weaken the factors of the negative impact on hepatocytes (the main liver cells): metabolic disorders, intoxication of the body and improper diet.

    “Alpha-lipoic acid serves as a comprehensive means of preventing fatty liver hepatosis”

    In 2013, Dr. Catirwell conducted a series of studies studying the effect of antioxidants on the formation of adipose tissue in the liver. During one of the experiments, experimental rodents with steatosis symptoms received lipoic acid in combination with levocarnitine (a natural chemical compound that corrects lipid metabolism) for 6 months. A comparison with the control group evaluated body weight, liver volume, percentage of adipose tissue and the extent of damage to internal organs.

    The results of studies showed that lipoic acid, thanks to the following effects, copes with steatosis even in the late stages of the disease:

    • Increases the content of mitochondria in the liver cells,
    • Normalizes energy metabolism,
    • Reduces lipid concentration
    • Accelerates the absorption of other antioxidants.

    Lipoic acid for liver diseases: instructions for use

    Normalize the functionality of the liver and gall bladder through the use of hepatoprotectors. Essential phospholipids, bile acids, amino acids are most often used.

    But many patients prefer drugs based on lipoic acid. Such medicines have anti-inflammatory, immunomodulatory, hepatoprotective and choleretic effects.

    Lipoic acid is available in tablet form. They produce medicine URALBIOFARM and MARBIOFARM. Domestic medicine has a relatively low cost - tablets cost about 80-100 rubles (50 tablets of 25 mg).

    The liver is not made of steel

    Liver is one of the vital organs of our body. Even in the distant past, traditional healers who attributed many of the painful signs of poor liver function found this out for themselves. Ultimately, the ritual ceremonies of some Indian tribes were associated with the use of raw liver (including enemies) as a source of strength and health.

    The liver function in our body is very important and indispensable. After all, everything that we eat, the liver must process. It breaks down all the substances that our body absorbs. But at the same time it eliminates metabolic waste, tries to remove from the body poisons or other toxic and alien substances that enter the body with food, alcohol, and medicines.

    The liver is our large chemical laboratory, where everything that we accept is burned, and where the energy necessary for our life is generated. A properly and well-functioning liver is the guarantee of our health and vitality.

    The lifestyle of most of our citizens and our eating habits, which are common causes of most of the "diseases of civilization", lead to great stress on the liver. Some of our abuses are “forgiven”, but when the liver is overloaded, an alarm is given, usually in the form of restless sleep and increased fatigue during the day.

    Later it happens that there is an increased level of fat in the blood and a gradual obesity of the liver (steatosis), which subsequently leads to its hardening (cirrhosis). Obesity, hyperemia and atrophy of liver functions, in the first place, are caused by excessive consumption of refined cereal products (especially white flour), refined sugar, saturated fats and meat.

    The yeast in many foods produces mycotoxins, which are especially dangerous for children and pregnant women. Once inside the body, they cause an increasing number of allergies, in particular asthma. They create the foundation for the development of many diseases, including the osteoarticular system, the genitourinary system, neurological diseases, pressure, hormonal problems, and, first of all, tumors.

    Your liver can protect you from these diseases, provided that it can successfully neutralize all chemical compounds. She is able to recover if food toxins do not interfere with her, and you provide her with all the necessary nutrients.

    Chemicals in foods, heavy metals, pesticides, viruses, pathogenic bacteria, nitrates and nitrides, as well as antibiotic residues, are also of great danger. Every day, our liver must fight them.

    If we add a beer to this, liver enzymes switch to neutralizing alcohol, as well as the knotweed often contained in it (very dangerous for the liver), as well as benzene in beer. The detoxification process of food toxins is significantly slowed down, and this slowdown facilitates the development of parasites and pathogens. The accumulation of toxins in the body creates an excessive load on the liver, which is no longer able to perform its functions.

    Obesity of the liver used to be considered, first of all, the problem of alcoholics, but nowadays it is becoming more common, especially in children. American doctors estimate that 50% of overweight children also have non-alcoholic liver obesity. This is bad, as it increases the risk of liver inflammation, which can develop into hepatitis and in some cases lead to liver failure. According to this study, 40 million Americans suffer from liver obesity.

    Things are not better in the CIS countries. In 2007, liver health was examined in 28 large cities of Russia, in which more than 30 thousand people took part. Doctors found overweight in 42% of the examined patients, in every second - liver disease, in every fourth - liver obesity, in every fifth - alcohol damage. Isn't it a bit much?

    There are also special moments when it is necessary to take additional measures to protect and regenerate the liver. For some, such a critical moment is protracted holidays, accompanied by abundant feasts, for others - courses of treatment with potent chemicals.

    Our doctors are used to prescribing chemical drugs that have a very strong effect and give a quick effect in the acute period of the disease. In this case, almost all drugs are foreign to the body and have side effects, which have to close your eyes. It must be remembered that all drugs give a temporary positive effect, support one or another organ, but then, playing their role, in the form of sharp fragments remain in the body and are not removed from anywhere. First of all, they affect the liver, clog the smallest vessels. And physiologists today say that the problem is not in the introduction of drugs into the body, but in how to remove them from it.

    You can bring your liver to a state where the destruction process is already difficult to reverse, and at the same time it will not ask for mercy. The fact is that the liver, collapsing, does not hurt (pains occur only with cholecystitis). The truth about the condition of your liver can be revealed by age spots that appear on the skin (usually the back of the hand). They are also sometimes called "liver". And this is correct, since they clearly demonstrate the deterioration of the liver. However, the liver, due to the critical nature of the functions it performs, is capable of cell regeneration.

    There are a number of natural remedies that help restore the liver and do not have any side effects. Here is what applies to them:

    1. Amino acids. In fact, 80% of the required amino acids are produced by the liver. The rest can enter the body only from the outside. Ten amino acids are absorbed only with food. They are called essential amino acids, these include arginine, phenylalanine, histidine, isoleucine, leucine, lysine, methionine, threonine, tryptophan and valine.

    Of the amino acids for liver repair, methionine is the most important, which regulates liver function, removes excess fat from the liver and accelerates the course of recovery processes. L-cysteine ​​also plays an important role, which helps to neutralize toxic substances and serves as a source for the production of glutathione, which has a protective effect on liver and brain cells from alcohol damage. L-carnitine causes steatohepatosis regression and normalizes the histological structure of the liver.

    Arginine and ornithine are also important for liver regeneration. Arginine helps detoxify the liver by neutralizing ammonia and serves as a source of proteins needed to create new cells. Ornithine acts as a hepatoprotector and prevents inflammation of the liver tissue. Arginine and ornithine mutually transform into each other in the so-called ornithine cycle, during which toxic ammonia is neutralized.

    The beneficial effect of amino acids on the liver is especially great in combination with lecithin and minerals - selenium and chromium.

    2. Lecithin. The lipotropic effect of one of its components - choline - is manifested in the "burning" of fats deposited in the liver. Lecithin is also necessary for the restoration of cell membranes, which is especially important in the rehabilitation of the liver. The liver, collapsing, does not give pain signals, so the patient does not even imagine to what degree the lesion is brought to his liver. When taking lecithin, the diseased liver reacts instantly: “twitching” is felt, then a slight aching pain that quickly passes. These symptoms suggest that the liver is recovering.

    3. Milk thistle. The properties of the flavonoid silymarin, which is part of the seeds of thistle (milk thistle, bruiser, "spicy"), are being intensively studied. Experimental and clinical studies have shown that silymarin helps restore damaged membranes of liver cells and prevents their damage by various toxins, promotes the birth of young liver cells, that is, the restoration of its cellular structure.It is no accident that workers in hazardous chemical industries are advised to take silymarin once a day.

    Milk thistle preparations have a strong choleretic (bile-forming) and choleretic effect, while they note their very good tolerance and the practical absence of contraindications to their use. The most striking therapeutic effect is exerted by milk thistle flavonoids in alcoholic liver disease.

    4. Alpha lipoic acid. Alpha-lipoic acid is a universal, liver-friendly antioxidant (its main metabolism is concentrated in the liver). It restores glutathione reserves, increases the resistance of hepatocytes, thereby increasing the antitoxic function of the liver. Alpha lipoic acid reduces the accumulation of fat in the liver and halves the risk of liver obesity with a high fat content in food.

    5. Resveratrol. A study published in the American Physiological Journal showed that resveratrol can prevent the development of fatty liver disease associated with chronic alcohol consumption. This antioxidant activates enzymes that play a role in the cellular metabolism and breakdown of fats in the liver - protein kinase and sirtuin. These enzymes inhibit the action of alcohol, which causes an increase and obesity in the liver.

    This probably explains the amazing fact that was reported by researchers from the University of San Diego (California). They found that a glass of wine a day could halve the risk of non-alcoholic obesity in the liver. And red wine is one of the first products in which resveratrol was discovered.

    6. Green tea. New experimental data show that green tea extract can prevent the accumulation of fatty deposits in the liver, thus preventing its fatty degeneration. The mechanism of its action is associated with a decrease in fat absorption in the intestine and a change in fat metabolism in the liver.

    If you feel that you have started up your liver and are anxious to bring it back to normal, there is a good way for this. First, drink a course of lecithin for a month to dissolve and remove fatty deposits. Then use the complex drug Liver Aid for detoxification and restoration of liver cells. ZenThonic is also recommended, which helps harmonize the functions of renewed cells.

    It’s better, of course, not to deal with liver problems. For this, there is only one way - to take up your lifestyle closely. Healthy liver and getting rid of bad habits your liver will take with a bang. And not only the liver.

    Postoperative pain relief

    Late stages of liver disease often require urgent surgery or transplantation. But even if the transplant was successful, the recovery period is accompanied by severe pain caused by mechanical damage to nerve fibers.

    At the same time, the risk of developing side diseases associated with insufficient functionality of the transplanted organs also increases.

    Regular administration of non-steroidal anti-inflammatory drugs, one of which is alpha lipoic acid, can alleviate the patient’s condition.

    "A clinical study in 811 patients with a transplanted kidney or liver showed that alpha lipoic acid reduces the severity of postoperative neuropathic symptoms."

    In 2017, Dr. Okal examined the data of 811 patients who participated in liver and kidney transplant procedures. He found that patients receiving lipoic acid in the postoperative period recovered faster and complained less of neuropathic disorders. He concluded that taking this substance has a complex therapeutic effect on such patients:

    • Accelerates the integration of donor tissue into the body of the carrier,
    • Reduces pain due to restoration of nerve fibers,
    • Provides a general strengthening effect on the liver and immunity in general.

    The therapeutic effect of lipoic acid allows its use against liver diseases caused by lipid peroxidation and metabolic disorders.

    But this is not the only property that this substance possesses.

    After reviewing the materials presented on the site, you can learn about the disorders that thioctic acid fights against, determine the dosage and method of use in each case.

    Diseases that lipoic acid fights

    How to take lipoic acid

    Lipoic acid against poisons and toxins

    Lipoic acid for what women need

    Lipoic acid looks like a light yellow powder, tastes bitter. This compound of sulfur with fatty acid is produced in the human body, but more and more doctors recommend its additional intake.

    The supplement gives energy, helps to lose weight, restores the health of internal organs, promotes rejuvenation and is practically harmless.

    It is worth it to take a closer look, to understand in what cases it can be taken with the maximum benefit for yourself.

    Why lipoic acid, why women need such therapy, in which cases it should be avoided, and how to choose the right drug, we will tell in this article.

    The properties

    Lipoic acid is involved in metabolism, by the method of influencing the processes taking place in the body, it is easiest to compare with vitamins from the B-group.

    It helps to regulate the processes of carbohydrate and fat metabolism in the body, eases the load on the liver and improves its work, removes decay products, toxins and toxins from the body.

    For this property it is used for severe poisoning to quickly remove hazardous substances. Participates in cholesterol metabolism, helps to lose weight due to lipotropic properties.

    Lipoic acid (also called alpha-lipoic or thioctic, vitamin N, lipamide) is an internal antioxidant that binds unnecessary free radicals. Lipamide lowers blood glucose and increases glycogen stores.

    • Inside the cells of the body, it acts on enzymatic reactions, helps to increase the energy received.
    • The substance controls the breakdown of amino acids, contributing to the effective absorption of all necessary substances and removes unnecessary residues from the body.
    • Lipamide preserves the health of DNA structures, preserves youth and body functions.

    This acid is formed in the human body, is actively involved in metabolic processes. With age, its production decreases.

    Lipoic acid for women after 50

    The need for acid increases significantly with age. From 40 to 50 years of age, depletion of the antioxidant system occurs and there is a need to combat free radicals, leading to aging and general wear and tear of the body. The daily dose for the prevention of 60-100 mg per day.

    With age, the number of diseases of the internal organs accumulates, the kidneys, the cardiovascular system and other important systems wear out. Under these conditions, lipoic acid is consumed at a high rate, which leads to the need for additional intake.

    Oxidative stress, living in big cities, unhealthy diet, and a tendency to junk food and unhealthy drinks also require an additional dose of lipoic acid. The daily norm can be 200-300 mg.

    In a situation of heavy physical exertion, from 100 to 600 mg per day are introduced into the menu.

    Daily norms of 300-600 mg are used in the treatment of age-related diseases such as Alzheimer's disease, diabetes, neuropathy, liver disease.

    The acid is introduced into the complex, facilitating the course of menopause. During this period, bone loss begins, the supplement increases the bone mineral density. According to experts, all age patients who tolerate it well, you need to add it to the diet to combat free radicals and as a preventive measure.

    Western neurologists recommend drinking up to 600 mg per day in adulthood for the prevention of senile brain problems and the correction of age-related changes accumulated in the body.

    With infertility in women

    With infertility in women, lipoic acid will help a couple conceive a healthy baby. In men, it improves sperm quality, which is important for a more confident conception and development of the embryo.

    Currently, more and more gynecologists include the drug in vitamin intake regimens during the planning and preparation of the body for pregnancy.

    Lipoic acid improves the effect of other drugs, cleanses the body of toxins, and reduces chronic inflammation.

    Important: during pregnancy, anemia is dangerous for the fetus, and doctors are trying to maintain and raise the level of iron in the body of the expectant mother.

    Taking alpha-lipoic acid lowers iron levels, so it is advisable to refuse it during pregnancy.

    To improve the general condition of the body, the course is drunk at the planning stage, during pregnancy, admission is possible only if necessary, as directed by a doctor.

    Lipoic acid for weight loss

    1. Despite the fact that the drug is not considered a means for weight loss, most often it is used during weight loss.
    2. It is believed that due to taking the supplement, there is a decrease in appetite, the mood is leveled, the fat reserve burns faster and the craving for sweets decreases.

  • Myths and Truth About Alpha Lipoic Acid:
    1. Decreased appetite. The substance normalizes blood sugar. Thanks to this action, the appetite is reduced and it is much more comfortable to transfer the time of the diet.
    2. Normalization of carbohydrate metabolism.

      Due to the intensive burning of reserves, the process of losing weight is accelerated, the tonus rises, and there is a surge of energy for further activity.

    3. Lipotropic effect. Thanks to the elimination of toxins and the improvement of liver function, health is improved.

    We can conclude: acid alone will not make the body lose weight.

    But if you turn on the process of losing weight, choosing the right diet and connecting sports loads, alpha lipoic acid will become a comfortable and pleasant addition.

    It is taken 25 mg before or immediately after sports activities as well as after eating. The maximum per day is 100 mg, the intake time is 3 weeks.

    • brewer's yeast
    • brown rice, brown, wild,
    • green vegetables: broccoli, spinach or brussels sprouts,
    • peas
    • tomatoes
    • offal: liver, kidney.

    Interaction with other drugs

    • Cisplatin: decreases the effectiveness of cisplatin.
    • Insulin and hypoglycemic agents: the action of insulin, as well as hypoglycemia, is enhanced.
    • Carnitine: the effect of carnitine is enhanced.
    • Ethanol: the effect of acid weakens or disappears.
    • Complete incompatibility: ethanol, ringer's solutions, dextrose.

    Important: acid removes magnesium and iron from the human body, it is advisable to supplement your diet with necessary supplements for those who suffer from anemia or need magnesium supplements for stable cardiac activity.

    Possible analogues

    In pharmacies you can find analogues of the usual drug called “Lipoic acid” in the form of tablets, capsules and solutions for injection. They contain the same substance, only the design, the degree of purification and dosage and the price differ.

    It is impossible to find another drug with the same properties, since it is an endogenous substance that is produced by the body itself.

    Popular analogues:

    The modern chemical industry produces two analogs of the additive with a mirror molecule, right and left. The name or description of drugs contains the Latin letters L or R.

    The “right” option is more expensive, but completely identical to the substance that is produced by the human body itself.

    Choosing such a drug, you need to reduce the recommended dosage by half, as it is easily absorbed.

    The “left” version acts more weakly, is absorbed worse and has almost no effect on the sensitivity of cells to insulin.

    In the case of alpha-lipoic acid, the drug seems very friendly and natural to the human body, but self-administration should be avoided. Consultation with your doctor will help you make the right decision, choose the right dosage and the appropriate form of administration.

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